PHYSICAL PHARMACEUTICS-I (Unit:- 1) Study Material
Solubility of drugs:
Solubility
expressions, mechanisms of solute solvent interactions, ideal solubility
parameters, solvation & association, quantitative approach to the factors
influencing solubility of drugs, diffusion principles in biological systems.
Solubility of gas in liquids, solubility of liquids in liquids, (Binary solutions,
ideal solutions) Raoult’s law, real solutions. Partially miscible liquids,
Critical solution temperature and applications. Distribution law, its
limitations and applications.
PHYSICAL
PHARMACEUTICS-I (Unit:- 2) Study
Material
States of Matter and properties of matter:
State of matter, changes
in the state of matter, latent heats, vapour pressure, sublimation critical
point, eutectic mixtures, gases, aerosols– inhalers, relative humidity, liquid
complexes, liquid crystals, glassy states, solid-crystalline, amorphous &
polymorphism.
Physicochemical
properties of drug molecules:
Refractive index, optical
rotation, dielectric constant, dipole moment, dissociation constant,
determinations and applications.
PHYSICAL
PHARMACEUTICS-I (Unit:- 3) Study
Material
Surface and interfacial phenomenon:
Liquid interface, surface
& interfacial tensions, surface free energy, measurement of surface &
interfacial tensions, spreading coefficient, adsorption at liquid interfaces,
surface active agents, HLB Scale, solubilisation, detergency, adsorption at
solid interface.
PHYSICAL
PHARMACEUTICS-I (Unit:- 4) Study
Material
Complexation and protein
binding:
Introduction,
Classification of Complexation, Applications, methods of analysis, protein
binding, Complexation and drug action, crystalline structures of complexes and
thermodynamic treatment of stability constants.
PHYSICAL
PHARMACEUTICS-I (Unit:- 5) Study
Material
pH, buffers and Isotonic
solutions:
Sorensen’s pH scale, pH
determination (electrometric and calorimetric), applications of buffers, buffer
equation, buffer capacity, buffers in pharmaceutical and biological systems,
buffered isotonic solutions.
(full-width)